If you don’t have the right items, it simply won’t do anything. To use the Horadric Cube, you need to place the correct group of materials inside the Cube and click the Transmute button at the bottom. For example, an Ancient’s Pledge (runeword) will cost Shields and 3 sockets(item) and Ral + Ort + Tal (rune) and can reach enhanced defense+50%, Cold resist +43%, Fire resist +48%, Lightning resist +48%, Poison resist +48%, 10% damage taken goes to mana (effects). And a large list of D2R items can be purchased from NPCs or drops from killing mobs and containers, but for rare and unique items or powerful runewords as mentioned earlier, you will need to have particular Horadric Cube recipes, which will take quite a lot of work to accomplish. Well, single runes can drop anywhere in Diablo 2: Resurrected, starting in Normal difficulty through to Hell difficulty. How do I get D2R items and D2R Runes in-game, you may ask? You also need to keep in mind that runes have a minimum character level, which means if your character doesn’t reach the level, the rune cannot be used, nor can the weapons and armors where the rune is in place be used. They can also be used in certain Horadric Cube recipes to repair and upgrade. Runes can be put into socketed gear to receive their effects and can be combined in a specific order in a specific item for their real magic (runewords they now become). Among the changes of the new expansion is the new ranked system, you had to reply on unique weapons and armor for endgame gear, and runes play a huge role in the online economy and in the power ranking of your characters-all these mentioned above are Diablo 2 Resurrected items, including Runes, Runewords, Charms, Jewels, Set Items (Weapons & Armors), Unique Items (Weapons & Armors), etc.
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